Monday Miscellaneous

In the line of wtf no really, here’s a quill that writes with blood

There’s something creepily fascinating about this pen: maybe its the jaunty feather attached at the end, or those plastic mechanics squeezing blood out of the syringe onto the nib.

Fascinating and disturbing.

On serotonin…

    1. Guess what? It helps activate platelets!

      Our data suggest that 5-HT per se does not activate platelets, but dose-dependently enhances platelet activation induced by ADP and, in particular, thrombin in whole blood. Thus, the idea that 5-HT is a ‘helper agonist’ is supported; this effect is mediated by 5-HT2A receptors.

    2. Common cold meds might just block serotonin reuptake

      Several mechanisms may have contributed to the development of serotonin syndrome in this patient. Firstly, dextromethorphan is a potent inhibitor of serotonin reuptake, similar to SSRIs. The combination with citalopram would therefore be expected to markedly increase the concentration of serotonin at the synapse. Secondly, SSRIs act as cytochrome P450 2D6 inhibitors, and although citalopram is a weak inhibitor, this may have contributed to elevated concentrations of dextromethorphan, which is a substrate of CYP 2D6.

    3. Your second brain, serotonin, and why SSRIs often cause gut upsets.

The enteric nervous system uses more than 30 neurotransmitters, just like the brain, and in fact 95 percent of the body’s serotonin is found in the bowels.

And finally….same day appointments at your local doctor’s? Is this really a thing? Apparently

The access model we created is often called “open access,” “advanced access” or “same-day scheduling.” It has one very simple yet challenging rule: Do today’s work today. Doing so enables patients to see their own personal physician on the day they call for any problem, whether urgent, routine or preventive. In less than one year, it reduced our 55-day wait to just one day, it increased dramatically the odds of patients seeing their own personal physician, and it improved physician, patient and staff satisfaction. We are even gathering evidence that it improves clinical outcomes as well.


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